当前位置:首页 >> 农林牧渔 >>


China Integrated Programs for Research on AIDS (China CIPRA)
美国国立卫生研究院国际综合性艾滋病研究计划资助 Comprehensive International Program of Research on AIDS



tline of China CIPRA
? CIPRA: Comprehensive International Program of Research on AIDS ? Sponsor: National Institute of Health, USA ? Corporation: National Center for STD/AIDS prevention and control, China CDC ? Period: July 1, 2002 to June 30, 2007 ? Budget: $15 millions ? Project provinces: Shanxi and Yunnan

Overall Goal
? To strengthen the existing HIV/AIDS research infrastructure in China and build the capacity to conduct multidisciplinary research to explore promising strategies for HIV/AIDS prevention, treatment and control.


Research Group
? The China CIPRA project is composed of 143 research staffs and 12 international consultants. ? The China CIPRA team is composed of 24 collaborating organizations including 13 domestic research institutes, 2 universities, and 2 hospitals, as well as 5 international universities and 2 research institutions.

Research Activity (I)
1. To estimate the prevalence and incidence of HIV-1 infection and to determine risk factors. 2. To evaluate the efficacy of more intensive, theoretically-based HIV skill-focused interventions for HIV+ adults. 3. To study viral and host factors that correlate with transmission of infection and factors that determine disease progression; and identify the immunodominant CTL epitopes and their MHC restricting elements in the most prevalent Chinese HIV subtypes as well as provide reagents for these studies. 5

Research Activity (II) 4. To characterize the clinical presentations of AIDS patients in China, to conduct clinical trials of antiviral drugs; 5. To develop vaccine candidates based on the Chinese prevalent strains and to conduct Phase I and Phase II clinical trials to evaluate its safety, immunogenicity and preliminary efficacy.


Research Team of China CIPRA
P I : Yiming Shao Co-PI : Dexian Zheng , Zunyou Wu Advisor: Yi Zeng

Core A (Administration and training)
Leader: Yiming Shao Co-Leader: Dexian Zheng Zunyou Wu Xiaoyan Zhang

Core B
(Statistical and Data Management) Leader: ShuiGao Jin Co-Leader: Hui Li Yuhua Ruan Consultant: Steve Self

Core C (Central Laboratory)
Leader: Yan Jiang Co-Leader: DeXian Zheng Consultant: Haynes W. Sheppard Huyen Cao

Core D (Primate)
Leader: Fude Fang Co-Leader: QiHan Li XinMing Tu Consultant: Ruth Ruprecht, Harold M.McClure, Xiaofang Yu

Project 1 (Epidemiology)
Leader: Xiwen Zheng Co-Leader: Zunyou Wu Lü Fan Shenghan Lai

Project 2 (Behaviroal Intervention)
Leader: Zunyou Wu Co-Leader and Consultant: Roger Detels Rotheram-Borus Mary Jane

Project 3
(Viral Immune Corrlates of
Transmission and Progression)

Project 4 (Clinical Research)
Leader: Yunzhen Cao Co-Leader: Taisheng Li Linqi Zhang Xiaoping Chen Consultant: David Ho

Project 5
(Development of a novel vaccine against HIV/AIDS in China) Leader: Li Ruan Co-Leader: Yiming Shao Wei He Yichen Lu Xiaofang Yu

Consultant: Sten Vermund
Roger Detels , ShenhanLai

Leader: Yiming Shao Co-Leader: Yunqi Geng Judy Lieberman Kunxue Hong , Xing Hui Consultant: Haynes W.Sheppard Huyen Cao


CIPRA Coordinating Committee(CCC) ( )
? The CCC is responsible for supervising the general research direction according to the goals of Chinese AIDS control and prevention effort. It will provide guidance and support for the implementation of the China CIPRA research protocol and schedule. In addition, the committee will translate the experiences and results of the China CIPRA program to help advance AIDS research throughout the country.

Scientific Advisory Board (SAB)
? Made up of independent domestic and international experts who are not affiliated with the research team. ? Responsibilities include:
assisting with the planning and implementation of the research protocol; receiving research progress reports on a regular basis; aiding in the resolution of research difficulties encountered; providing an independent assessment on a regular basis of the current status of research project


Monitoring Group on Quality Control (MGQC)
? This committee is composed of Chinese and international experts and is in charge of maintaining the quality of data generated from this project. The main responsibility of this group is to supervise the quality of the study based on the overall aims and goals of the China CIPRA plan. They will oversee quality control in the following areas: epidemiology, laboratory techniques, experiment quality, clinical studies, and particular research related to the GCP standards. This group will also evaluate the appropriateness of the consent forms and any pertinent ethical issues. They will scrutinize and provide feedback to the researchers to assure the future quality of the research.


Network of China-CIPRA Operational Systems
National Institutes of Health (NIH)

CIPRA Coordinating Committee (CCC)

CIPRA Executive Committee (CEC)

Scientific Advisory Board (SAB)

Study Plan/Protocol Ethic Committee (EC)

Study Implementation (Project and Core Activities) Community Advisory Board(CAB) Monitoring Group on Quality Control (MGQC)

Supervision Action


Study Population


Summary of Progress
? ? ? ? ? Set up the administration structure and research team; Conducted preparation work at Shanxi local sites; Developed research protocols; Created SOPs for CIPRA team (on going); Organized training according to the plan;IRB, GCP, management, research techniques, etc. Some researchers were trained oversea ? Strengthened communication among projects and cores, and communication with international organizations. Created web site and newsletter (electronic/paper version).

Training Information Welcome
? ? ? ? Project Management and Coordination Leadership and Organization 2 to 3 month/course advanced course preferred


Contact information
Address: 4 Nan Wei Road, Room 510 Xuan Wu District Beijing, China 100050 Tel: 86-10-63045970; ; 63015577 ex. 6510 Fax: 86-10-63045970 E-mail: cipracn@public3.bta.net.cn Website: http://www.chinaids.org.cn/cipra



国内外艾滋病研究进展摘要:艾滋病,即获得性免疫缺陷综合征,英文名称 Acquired ...1995 年中国艾滋病感染人数从此前的几百例一下子蹿 升到 1567 例,其中绝大...
2002中国医药科技十大成果(上)_医药卫生_专业资料。2002中国医药科技十大成果(上...二、获准启动全球第一个超大型综合性国际艾滋病研究项目 旨在综合全世界艾滋病...
扩大综合干预覆盖面、 扩大抗病毒治疗覆盖面, 加强血液...AIDS 预防控制项目的工作重点、难点和关键环节, 也是...(2009),艾滋病社会支持的研究现状及实践评价,中国...
(3)与 HIV 疫苗设计相关的 HLA 分型和表位作图研究 ,(HLA typing and epitope mapping relative to HIV) (95 万美元) 和(4)中国综合性艾滋病研究项目(...
研究机构和非政府组织的伙伴合作力度,开展综合艾滋病防治活动,全方位 协助中国...活动 内容涉及艾滋病治疗的临床研究和公共及社区防治教育项目等。例如,葛兰素史 ...
中国艾滋病治疗药物市场竞争调研与发展趋势研究报告(2013-2017) 中国艾滋病治疗药物市场竞争调研与 发展趋势研究报告(2013-2017) 中国报告网 出版时间:2013 年 中国...
中国预防医学科学院确诊,他患的是艾滋病胃肠综合...已经有许多流行病学研究显示 , 在中国由妓女传播的...相关的预防工作和治疗项目可能应当马上抵达这个易感群体...
2015-2020年中国艾滋病药市场研究与发展前景预测...研究某一行业发展动态、规模结构、竞争格局以及综合 ...c)超过 200 多个研究项目的成功案例 d)研究领域...
综合各种资料、第 12,13 天:总 结结题报告 6班 六、调查结果 研究物体 艾滋病, 即获得性免疫缺陷综合症 (又译: 后天性免疫缺陷症候群) 英语缩写 AIDS ,(...
中国艾滋病研究成果 | 综合性研究 | 综合性学习研究报告 | 综合性研究型大学 | 综合性研究报告 | 综合性遗产保护的研究 | 中国项目研究网 | 中国项目可行性研究网 |